Based on the analysis of the provided academic publications, here’s a summary of the key points:
1. Key Benefits and Effects: Creatine supplementation has been found to enhance cognitive function, specifically in areas of memory and intelligence (Avgerinos et al., 2018). It may also improve athletic performance and aid in the treatment of neurological diseases (Kreider & Stout, 2021). In patients with colorectal cancer, creatine supplementation can improve muscle function and overall quality of life (Norman et al., 2006). There is also some evidence suggesting that creatine may offer protection against neurological and atherosclerotic diseases (Wyss & Schulze, 2002). However, it was found to have no significant impact on the progression of ALS (Shefner et al., 2004).
2. Safety Considerations: Across the studies, creatine supplementation has been found to be safe when used appropriately. No significant adverse effects have been reported in the patient populations studied, including those with ALS (Shefner et al., 2004) and colorectal cancer (Norman et al., 2006).
3. Recommended Usage: The studies do not provide specific dosage recommendations for creatine supplementation. However, they emphasize its safe usage when used appropriately. It is always recommended to follow the manufacturer’s instructions or consult with a healthcare professional for personalized advice.
4. Scientific Strength of Evidence: The strength of the scientific evidence varies across the studies, with credibility scores ranging from 6.88 to 9.01. The studies consistently report potential benefits of creatine supplementation and its safety. However, they also highlight the need for further research to fully understand the mechanisms of action and to confirm the efficacy of creatine supplementation in different contexts.
In conclusion, creatine supplementation appears to have several potential benefits, particularly for cognitive function, athletic performance, and certain health conditions. It is generally considered safe, but as with any supplement, it should be used responsibly. Further research is needed to fully understand its effects and optimal usage. As always, individuals should consult with a healthcare professional before starting any new supplement regimen.
Effects of creatine supplementation on cognitive function of healthy individuals: A systematic review of randomized controlled trials
The 2018 publication by Avgerinos, Spyrou, and Bougioukas systematically reviewed randomized controlled trials to study the effects of creatine supplementation on cognitive function in healthy individuals. The key findings suggest that creatine supplementation may enhance cognitive function, specifically in areas of memory and intelligence. However, the authors highlight the need for further research to fully understand the mechanisms of action and to confirm the safety and efficacy of creatine supplementation for cognitive enhancement.
A clinical trial of creatine in ALS
The 2004 study “A clinical trial of creatine in ALS” by JM Shefner, ME Cudkowicz, D Schoenfeld, and T Conrad, published in Neurology, investigated the effects of creatine supplementation in patients with Amyotrophic Lateral Sclerosis (ALS). The key findings suggested that creatine had no significant impact on the progression of ALS. The study also confirmed the safety of creatine supplementation in this patient population. Despite the lack of efficacy in slowing ALS progression, the research contributes to understanding the potential uses and limitations of creatine supplementation in neurodegenerative diseases.
Creatine in health and disease
The 2021 publication “Creatine in Health and Disease” by RB Kreider and JR Stout in the journal Nutrients explores the health benefits, mechanisms of action, safety, and usage of creatine. The key findings highlight creatine’s role in enhancing athletic performance, cognitive function, and aiding in the treatment of neurological diseases. The authors also discuss the safety of creatine supplementation, emphasizing its low risk when used appropriately. The mechanisms of action of creatine, particularly its role in energy metabolism, are also explored.
… of creatine supplementation on nutritional status, muscle function and quality of life in patients with colorectal cancer—A double blind randomised controlled trial
This 2006 study by Norman et al. in Clinical Nutrition investigated the impact of creatine supplementation on patients with colorectal cancer. The key findings suggest that creatine supplementation can improve muscle function and overall quality of life in these patients. It was also found to be safe for use in this patient population. The mechanisms of action, however, were not explicitly discussed in the publication.
Health implications of creatine: can oral creatine supplementation protect against neurological and atherosclerotic disease?
The 2002 study by M Wyss and A Schulze, published in Neuroscience, explores the potential health benefits of oral creatine supplementation. The authors suggest that creatine may offer protection against neurological and atherosclerotic diseases. The mechanisms of action include energy metabolism support in brain and heart tissues, and antioxidant activity. The study also emphasizes the safety of creatine supplementation. However, the authors recommend further research to fully understand its usage and effects.
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