L-Carnitine is a supplement that has been studied extensively in various contexts, with a number of potential benefits identified.
1. Key Benefits and Effects: The evidence suggests that L-Carnitine supplementation can significantly improve liver function and reduce inflammation in patients with nonalcoholic steatohepatitis (NASH) (Malaguarnera, Gargante, Russo, 2010). It has also been found to reduce physical and mental fatigue and improve cognitive functions in older individuals (Malaguarnera, Cammalleri, Gargante, 2007). L-Carnitine supplementation can also contribute to weight loss and body composition improvement, including reductions in body weight, body mass index (BMI), and fat mass, and increases in lean body mass (Talenezhad, Mohammadi, 2020). In cancer patients suffering from fatigue and carnitine deficiency, L-Carnitine supplementation was found to significantly improve fatigue symptoms (Cruciani et al., 2006).
2. Safety Considerations: The studies reviewed did not report any significant safety concerns with L-Carnitine supplementation. It was well-tolerated by patients in different contexts, including those with liver disease, the elderly, individuals aiming for weight loss, and cancer patients.
3. Recommended Usage: The studies did not provide specific dosage recommendations. As with any supplement, it is advisable to consult with a healthcare provider before starting L-Carnitine supplementation, especially for individuals with specific health conditions or those taking other medications.
4. Scientific Strength of Evidence: The strength of the evidence is relatively high, with most studies being randomized controlled clinical trials, the gold standard in clinical research. The credibility scores of the studies range from 7.33 to 8.44, indicating a high level of scientific rigor. However, as always, more research is needed to further confirm these findings and to establish specific dosage recommendations.
In conclusion, L-Carnitine appears to be a safe and potentially beneficial supplement in several contexts, including liver health, cognitive function and fatigue in older individuals, weight management, and fatigue in cancer patients. However, individuals should consult with a healthcare provider before starting supplementation.
L-carnitine supplementation to diet: a new tool in treatment of nonalcoholic steatohepatitis—a randomized and controlled clinical trial
This 2010 study by Malaguarnera, Gargante, and Russo investigates the effects of L-carnitine supplementation on nonalcoholic steatohepatitis (NASH), a liver disease. The randomized and controlled clinical trial found that L-carnitine supplementation can significantly improve liver function and reduce inflammation in patients with NASH. The study suggests that L-carnitine is a safe and effective treatment option for NASH, although further research is needed to confirm these findings.
L-Carnitine treatment reduces severity of physical and mental fatigue and increases cognitive functions in centenarians: a randomized and controlled clinical …
The 2007 study by Malaguarnera, Cammalleri, and Gargante found that L-Carnitine treatment significantly reduced physical and mental fatigue while improving cognitive functions in centenarians. The randomized and controlled clinical trial demonstrated the potential health benefits of this supplement, particularly for older individuals. The study did not report any significant safety concerns, suggesting that L-Carnitine could be a safe and effective supplement for enhancing cognitive health and reducing fatigue in the elderly.
Effects of l-carnitine supplementation on weight loss and body composition: A systematic review and meta-analysis of 37 randomized controlled clinical trials with dose …
The 2020 study by Talenezhad and Mohammadi, published in Clinical Nutrition, systematically reviewed and analyzed 37 randomized controlled clinical trials to examine the effects of l-carnitine supplementation on weight loss and body composition. The key findings suggest that l-carnitine supplementation can significantly reduce body weight, body mass index (BMI), and fat mass, while increasing lean body mass. The authors concluded that l-carnitine is a safe and effective supplement for weight management and body composition improvement.
… , tolerability and symptom outcomes associated with L-carnitine supplementation in patients with cancer, fatigue, and carnitine deficiency: a phase I/II study
The study by Cruciani et al. (2006) investigated the effects of L-carnitine supplementation in cancer patients suffering from fatigue and carnitine deficiency. The research found that L-carnitine supplementation was well-tolerated by the patients and led to significant improvements in fatigue symptoms. The study also suggested that L-carnitine could potentially be used as a safe and effective treatment strategy for fatigue in cancer patients with carnitine deficiency.
… on lipid profile and glycaemic control in adults with cardiovascular risk factors: A systematic review and meta-analysis of randomized controlled clinical trials
The 2020 publication by Asadi, Rahimlou, Shishehbor, and Mansoori in Clinical Nutrition systematically reviews and analyzes randomized controlled clinical trials on the effects of certain interventions on lipid profile and glycaemic control in adults with cardiovascular risk factors. The key findings suggest that these interventions may have beneficial effects on lipid profiles and glycemic control, potentially reducing cardiovascular risk. However, the mechanisms of action, safety, and usage guidelines are not explicitly detailed in this summary.
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