Based on the analysis of the provided academic publications, the following key points can be made about Methylsulfonylmethane (MSM):
1. Key Benefits and Effects: MSM has been found to have significant benefits in reducing pain and improving physical function in patients with osteoarthritis of the knee. It also appears to reduce exercise-induced muscle damage and oxidative stress, and alleviate post-exercise pain. These benefits are potentially due to MSM’s anti-inflammatory and antioxidant properties.
2. Safety Considerations: The studies reviewed suggest that MSM is safe for human consumption, with minimal side effects reported. However, as with any supplement, it should be taken under the guidance of a healthcare professional.
3. Recommended Usage: While the studies indicate positive effects of MSM supplementation, they do not provide specific dosage recommendations. Therefore, it is advisable to follow the manufacturer’s instructions or consult with a healthcare provider for personalized advice.
4. Scientific Strength of Evidence: The credibility scores of the studies range from 7.3 to 8.4, indicating a relatively high level of scientific evidence supporting the benefits and safety of MSM. However, some studies noted the need for further research to fully understand the mechanisms of action and to establish definitive usage guidelines.
In conclusion, MSM appears to be a promising supplement for managing osteoarthritis pain and reducing exercise-induced muscle damage, with a good safety profile. However, individuals should consult with a healthcare provider before starting any new supplement regimen.
Efficacy of methylsulfonylmethane (MSM) in osteoarthritis pain of the knee: a pilot clinical trial
The 2006 pilot clinical trial by LS Kim, LJ Axelrod, P Howard, and N Buratovich investigated the effectiveness of methylsulfonylmethane (MSM) in managing osteoarthritis pain in the knee. The study found that MSM significantly reduced pain and improved physical function without notable side effects, suggesting it could be a safe and beneficial supplement for osteoarthritis patients. The mechanisms of action, however, were not fully explored in this study.
Effects of Methylsulfonylmethane (MSM) on exercise-induced oxidative stress, muscle damage, and pain following a half-marathon: a double-blind, randomized …
The study by Withee et al. (2017) investigated the effects of Methylsulfonylmethane (MSM) on exercise-induced oxidative stress, muscle damage, and pain following a half-marathon. The research found that MSM supplementation significantly reduced muscle damage and oxidative stress markers, while also alleviating post-exercise pain. The study suggests that MSM is safe and beneficial for reducing pain and damage in muscles after intense exercise, potentially due to its anti-inflammatory and antioxidant properties.
Systematic review of the nutritional supplements dimethyl sulfoxide (DMSO) and methylsulfonylmethane (MSM) in the treatment of osteoarthritis
The 2008 study by Brien, Prescott, Bashir, and Lewith systematically reviewed the use of nutritional supplements dimethyl sulfoxide (DMSO) and methylsulfonylmethane (MSM) in treating osteoarthritis. The key findings suggest that both DMSO and MSM may have therapeutic benefits in managing osteoarthritis, possibly due to their anti-inflammatory and analgesic properties. However, the authors also noted that further research is required to confirm these benefits and to establish safety and usage guidelines.
Efficacy of methylsulfonylmethane supplementation on osteoarthritis of the knee: a randomized controlled study
The study by Debbi et al. (2011) investigated the effectiveness of methylsulfonylmethane (MSM) supplementation on knee osteoarthritis. The randomized controlled trial found that MSM supplementation significantly reduced pain and improved physical function in patients with osteoarthritis of the knee. The authors concluded that MSM is safe and effective for improving pain and physical function in patients suffering from knee osteoarthritis.
Methylsulfonylmethane: applications and safety of a novel dietary supplement
The 2017 study by Butawan, Benjamin, and Bloomer, published in Nutrients, explores the applications and safety of Methylsulfonylmethane (MSM), a novel dietary supplement. The authors found that MSM has anti-inflammatory and antioxidant properties, which can provide health benefits such as reducing joint pain and muscle damage. The study also confirmed that MSM is safe for human consumption, with minimal side effects. The authors suggest that MSM could be used as a dietary supplement to improve overall health and well-being.
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