MSM

Based on the analysis of the provided academic publications, the following key points can be made about Methylsulfonylmethane (MSM):

1. Key Benefits and Effects: MSM has been found to have significant benefits in reducing pain and improving physical function in patients with osteoarthritis of the knee. It also appears to reduce exercise-induced muscle damage and oxidative stress, and alleviate post-exercise pain. These benefits are potentially due to MSM’s anti-inflammatory and antioxidant properties.

2. Safety Considerations: The studies reviewed suggest that MSM is safe for human consumption, with minimal side effects reported. However, as with any supplement, it should be taken under the guidance of a healthcare professional.

3. Recommended Usage: While the studies indicate positive effects of MSM supplementation, they do not provide specific dosage recommendations. Therefore, it is advisable to follow the manufacturer’s instructions or consult with a healthcare provider for personalized advice.

4. Scientific Strength of Evidence: The credibility scores of the studies range from 7.3 to 8.4, indicating a relatively high level of scientific evidence supporting the benefits and safety of MSM. However, some studies noted the need for further research to fully understand the mechanisms of action and to establish definitive usage guidelines.

In conclusion, MSM appears to be a promising supplement for managing osteoarthritis pain and reducing exercise-induced muscle damage, with a good safety profile. However, individuals should consult with a healthcare provider before starting any new supplement regimen.