Based on the analysis of the provided academic publications, the following conclusions can be drawn:
1. Key Benefits and Effects: Selenium supplementation has been shown to have potential therapeutic benefits in treating multiple diseases such as cancer, HIV, cognitive decline, and thyroid disease (Sanmartín, Plano, & Font, 2011). It is crucial for the optimal function of various physiological processes due to its incorporation into selenoproteins (Rayman, 2012). However, its effect on musculoskeletal health in older women and overall mortality rate is not significant (Walsh, Jacques, & Schomburg, 2021; Rayman, Winther, & Pastor-Barriuso, 2018).
2. Safety Considerations: The safety of selenium supplementation has been confirmed in the studies (Sanmartín, Plano, & Font, 2011; Walsh, Jacques, & Schomburg, 2021). However, potential risks of excessive selenium intake have been noted, suggesting a U-shaped relationship between selenium status and health effects (Rayman, 2012).
3. Recommended Usage: The optimal selenium status can be achieved through supplementation, but the exact dosage and usage guidelines remain unclear and require further research (Hurst, Armah, Dainty, & Hart, 2010).
4. Scientific Strength of Evidence: The strength of the evidence varies across the studies, with credibility scores ranging from 7.35 to 8.49. The evidence suggests potential benefits of selenium supplementation, particularly in treating certain diseases and in regions with low selenium intake. However, the lack of significant findings in some areas (e.g., musculoskeletal health, overall mortality) and the need for further research on optimal dosage and usage guidelines indicate that the scientific strength of the evidence is moderate.
In conclusion, selenium supplementation may offer certain health benefits, particularly for individuals with specific diseases or in regions with low selenium intake. However, it’s important to consider potential risks associated with excessive intake. As always, it’s recommended to consult with a healthcare provider before starting any new supplement regimen.
Selenium and clinical trials: new therapeutic evidence for multiple diseases
This 2011 publication by Sanmartín, Plano, and Font explores the therapeutic benefits of selenium in treating multiple diseases. The authors present evidence from clinical trials demonstrating selenium’s potential in mitigating conditions such as cancer, HIV, cognitive decline, and thyroid disease. The paper also discusses the mechanisms of action of selenium, its safety, and usage. The study underscores the importance of selenium supplementation in enhancing health outcomes.
Effect of selenium supplementation on musculoskeletal health in older women: a randomised, double-blind, placebo-controlled trial
The study by Walsh, Jacques, and Schomburg (2021) investigated the impact of selenium supplementation on musculoskeletal health in older women. The randomized, double-blind, placebo-controlled trial found that selenium supplementation had no significant effect on musculoskeletal health. The safety of selenium supplementation was confirmed, but its usage for improving musculoskeletal health in older women is not supported by the findings of this study.
Establishing optimal selenium status: results of a randomized, double-blind, placebo-controlled trial
The 2010 study “Establishing optimal selenium status: results of a randomized, double-blind, placebo-controlled trial” by R Hurst et al. investigated the health benefits and safety of selenium supplementation. The key findings suggest that selenium supplementation can help achieve optimal selenium status, which is associated with various health benefits. However, the mechanisms of action remain unclear and further research is needed to determine safe usage guidelines.
Effect of long-term selenium supplementation on mortality: results from a multiple-dose, randomised controlled trial
This 2018 study by Rayman, Winther, and Pastor-Barriuso investigated the impact of long-term selenium supplementation on mortality. The randomized controlled trial found no significant effect on overall mortality from selenium supplementation. However, the study did note a potential reduction in cancer mortality with high-dose selenium supplementation, suggesting a possible protective effect. The authors emphasized the need for further research to confirm these findings and assess safety.
Selenium and human health
The 2012 publication “Selenium and Human Health” by MP Rayman in The Lancet highlights the significant role of selenium in human health. The study found that selenium, a trace element, is crucial for the optimal function of various physiological processes due to its incorporation into selenoproteins. The publication also emphasizes the potential health benefits of selenium supplementation, particularly in regions where selenium intake is low. However, it also cautions about the potential risks of excessive selenium intake, suggesting a U-shaped relationship between selenium status and health effects.
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